Between 1537 and 1880 Comayagua was the capital of Honduras. It still retains many interesting sights that serve as evidence of its important past. Comyagua's cathedral is the city's most prominent landmark. It was built between 1685 and 1715 and it contains a number of fine art pieces, as well as one of the world's oldest clocks. The Moors made the clock in the 12th century for the Alhambra palace in Granada (Spain). King Philip II of Spain later donated it to Comayagua.

Comayagua's first university was founded in 1632. It was housed in the Casa Rural, which is now home to the Museo Colonial. The museum has an excellent exhibition on 400 years of colonial rule. The oldest church in town is La Merced, which was constructed between 1550 and 1558. Other nice churches are La Caridad (1730) and San Francisco (1584).

There are several hotels and restaurants in Comayagua. The city is 65 km northwest of Tegucigalpa.